Hepatic Lipidosis (Fatty Liver)
Hepatic lipidosis is an abnormal accumulation of lipids (fat) in hepatocytes (liver cells). It is a common disease in cats (the most common liver disease diagnosed in cats in North America).
The disease is typically seen in overweight/obese cats that are anorexic/inappetent. The disease can either be primary (idiopathic) or secondary to many different diseases. Basically, any disease that will cause an obese cat not to eat can lead to secondary hepatic lipidosis. The most common diseases that are associated with secondary hepatic lipidosis are pancreatits, diabetes mellitus, diabetic ketoacidosis, inflammatory bowel disease, cholangitis/cholangiohepatitis (an inflammation of the bile duct) and neoplasia.
The pathophysiology of this disease is not fully understood and probably has more than one factor. In a nutshell, cats evolved as predators that eat small meals around the day. Therefore, their physiology is compatible with a completely carnivorous diet that would sustain a lean animal that would never be overweight. Domestic cats, however, have the possibility to become obese and when they stop eating, for any reason, it could lead to a serious problem. Normally, when an animal is starving, the body moves fat from its storage depot to the liver, where it is metabolized into lipoproteins. The feline liver was not designed to handle such great amounts of mobilized fat so it becomes infiltrated with fat and fails.